WIMBLEDON, England (AP) — Two-time Wimbledon champion Andy Murray has lost in the second round to big-serving American John Isner. It is Murray’s earliest loss in 14 appearances at the All England Club. No. 3 seed Casper Ruud also lost in the second round Wednesday, just weeks after being the runner-up to Rafael Nadal at the French Open. Prior to Murray vs. Isner, the host country’s other leading player, reigning U.S. Open champion Emma Raducanu, was eliminated by Caroline Garcia of France 6-3, 6-3.