TOKYO (AP) — Global shares are subdued as trading activity is reduced as U.S. markets remained closed for the Thanksgiving holiday. Benchmarks Europe were little changed on Thursday after Asia largely closed higher. Japan’s Nikkei 225 finished at its highest level in nearly three decades, since the nation’s “bubble economy” collapsed. U.S. markets will be closed Thursday and open for a half day on Friday. The recent upbeat mood has been set off by news of the development of coronavirus vaccines and treatments. But mixed economic data has also driven home the fact that the economic damage from the pandemic will take time to heal.